pentobarbital will lower the level or impact of eplerenone by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unknown. ??????? ?? ?? ?? ??? ??? ? ??. ?? ??? ????? ??? ??? ????. ??, ??????? ????? ?? ???? ?? ??? ?? ??? ????? ?? ??? ??. pentobarbital will lower the ext